Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction
نویسندگان
چکیده
منابع مشابه
Autologous intramyocardial injection of cultured skeletal muscle-derived stem cells in patients with non-acute myocardial infarction.
AIM Experimental animal studies suggest that the use of skeletal myoblast in patients with myocardial infarction may result in improved cardiac function. The aim of the study was to assess the feasibility and safety of this therapy in patients with myocardial infarction. METHODS AND RESULTS Twelve patients with old myocardial infarction and ischaemic coronary artery disease underwent treatmen...
متن کاملTransplantation of Cardiogenic Pre-Differentiated Autologous Adipose-Derived Mesenchymal Stem Cells Induced by Mechanical Loading Improves Cardiac Function Following Acute Myocardial Infarction in Rabbit Model
Objective- Investigate myocardial performance after autologous adipose-derived (ASCs) mesenchymal stem cell differentiated under equiaxial cyclic strain, transplantation in rabbits with acute myocardial infarction (AMI). Design- Prospective, randomized experimental study Animals- 20 New Zealand White rabbits (2-3 kg) P...
متن کاملCardiac repair with intramyocardial injection of allogeneic mesenchymal stem cells after myocardial infarction.
Although clinical trials of autologous whole bone marrow for cardiac repair demonstrate promising results, many practical and mechanistic issues regarding this therapy remain highly controversial. Here, we report the results of a randomized study of bone-marrow-derived mesenchymal stem cells, administered to pigs, which offer several new insights regarding cellular cardiomyoplasty. First, cells...
متن کاملIntramyocardial Injection of Stem Cells in Pig Myocardial Infarction Model: The First Trial in Korea
Although cell therapy is emerged for cardiac repair, its efficacy is modest by intracoronary infusion. Therefore, we established the intramyocardial delivery technique using a left ventricular (LV) mapping system (NOGA® XP) using 18 pigs. After adipose tissue-derived mesenchymal stem cells (ATSCs) were delivered intramyocardially to porcine infarcted heart, LV ejection fraction (EF) was increas...
متن کاملIntramyocardial injection of heart-derived extracellular matrix combined with cardiosphere-derived cells improves myocardial structure and function in rats with acute myocardial infarction
This study aimed to investigate the cardioprotective effects of intramyocardial injection of heart derived extracellular matrix (ECM) and cardiosphere-derived cells (CDCs) in a rat model of myocardial infarction (MI). ECM and CDCs were collected from the rat heart, and the proliferation, apoptosis and morphology of CDCs maintained on ECM were characterized in vitro. MI model was established in ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: European Heart Journal
سال: 2003
ISSN: 0195-668X
DOI: 10.1016/j.ehj.2003.09.012